Rustbelt CFAR Publications

Harnessing albumin as a carrier for the delivery of anti-HIV drugs to the lymphatic system

Zhang Z, Huang Y, West RE, Mahesh D, Oberly PJ, Li S, Luo Z, Chen Y, Huang H, Bain DJ, Nolin TD, Bility M, Mailliard RB, Li S. Acta Biomater. 2026;209:521-531. PMID: 41241114.

Complete CD16A Deficiency and Defective NK Cell Function in a Man Living with HIV

Zhang W, Scott AF, Mohr DW, Ingersoll R, Bream J, Shoucair PE, Nilles TL, Zhang H, Chen Y, Mailliard RB, Joseph B. Margolick. J Clin Immunol. 2025;45:98. PMID: 40411624. PMCID: PMC12103316.

HIV-1 testing in the context of expanding PrEP modalities

Parikh UM, Jacobs JL, Njuguna N, Torjesen K, Mellors JW. J Int AIDS Soc. 2025;28 Suppl 2:e26491. PMID: 40600472. PMCID: PMC12215806.

Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals

Neverette NC, Dumond JB, McMahon DK, Devanathan AS. Clin Pharmacol Ther. 2025;117:353–367. Published online 2024 Sep 25. doi: 10.1002/cpt.3447. Correction in: Clin Pharmacol Ther. 2025;117:1470. PMCID: PMC11739746.

Human memory CD4+ T-cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses

Stetsenko V, Gail DP, Reba S, Suzart VG, Sandhu AK, Sette A, Dezfulian MH, Lindestam Arlehamn CS, Carpenter SM. Version 1. bioRxiv. Preprint. 2025:2025.02.23.639515. PMCID: PMC11888249.

Protocol for the intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4+ T cell model.

Mbonye U, Agaponova A, Yang M, and Karn J. STAR Protoc. 2024;5:103398. PMID: 39425934. PMCID: PMC11513541.

Deciphering the role of endothelial granulocyte macrophage-CSF in chronic inflammation associated with HIV.

Panigrahi S, Mayne E, Louw S, Funderburg NT, Chakraborty A, Jacobson JM, Carpenter SM, Lederman MM, Freeman ML, Sieg SF. iScience. 2024;27:110909. PMID: 39391731. PMCID: PMC11465086.

The Current Pipeline of Antiretroviral Therapy: Expanding Options and Filling Gaps.

Li Y, Choudhary M, Mellors JW. Infect Dis Clin North Am. 2024;38:395-408. PMID: 38876905.

Persistence of a skewed NK cell repertoire in people with HIV on long-term ART

Anderko RR, DePuyt AE, Bronson R, Bullotta AC, Aga E, Bosch RJ, Jones RB, Gandhi RT, McMahon DK, Macatangay BJ, Rinaldo CR, Mailliard RB. J Immunol. 2024;212:1564-1578. PMID: 38551350. PMCID: PMC11073922.

Simultaneous quantification of five antiretrovirals in human tissues using ultra-high performance liquid chromatography-tandem mass spectrometry methods for therapeutic drug monitoring at the sites of action.

West 3rd RE, Oberly PJ, Saylor AJ, Riddler SA, Nolin TD, Devanathan AS. J Chromatogr B Analyt Technol Biomed Life Sci. 2024;1241:124164. PMID: 38823149. PMCID: PMC11215648.

Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation.

Kizito F, Nguyen K, Mbonye U, Shukla M, Luttge B, Checkley MA, Agaponova A, Leskov K, Karn J. Proc Natl Acad Sci U S A. 2024;121:e2202003121. PMID: 38669184. PMCID: PMC11067448.

Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses.

Meyerowitz EA, Li Y. Clin Infect Dis. 2024;78:908-917. PMID: 37949817; PMCID: PMC11487108.

The cell biology of HIV-1 latency and rebound.

Mbonye U, Karn J. Retrovirology. 2024;21:6. PMID: 38580979. PMCID: PMC10996279.

Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods to quantify antiretroviral therapy concentrations in human plasma for therapeutic drug monitoring.

West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. J Pharm Biomed Anal. 2024;240:115932. PMID: 38198884. PMCID: PMC10922569.

SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency.

Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. Sci Transl Med. 2024;16:eadk1599. PMID: 38266109. PMCID: PMC10982957.

SARS-CoV-2 Viral Clearance and Evolution Varies by Extent of Immunodeficiency

Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynold Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. Version 2. medRxiv [Preprint]. 2023:2023.07.31.23293441. PMID: 37577493. PMCID: PMC10418302.

SARS-CoV-2 mRNA Vaccines Induce Greater Complement Activation and Decreased Viremia and Nef Antibodies in Men With HIV-1

Tuttle DJ, Castanha PMS., Nasser A, and Wilkins MS, Alaoui-El-Azher M, and Cuff DE, Chhibbar P, Das J, Li Y, Barratt-Boyes SM, Mailliard RB, Sluis-Cremer NP, Rinaldo CR, Marques ETA. J Infect Dis. 2023;229:1147-1157. PMID: 38035792. PMCID: PMC11011180.

Viral and host mediators of non-suppressible HIV-1 viremia.

Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Nat Med. 2023;29:3212-3223. PMID: 37957382. PMCID: PMC10719098.

Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: application to therapeutic monitoring.

West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. J Chromatogr B Analyt Technol Biomed Life Sci. 2023;1230:123905. PMID: 37866010. PMCID: PMC10842204.