Rustbelt CFAR Publications
HIV-1 testing in the context of expanding PrEP modalities
Parikh UM, Jacobs JL, Njuguna N, Torjesen K, Mellors JW. J Int AIDS Soc. 2025;28 Suppl 2:e26491. PMID: 40600472. PMCID: PMC12215806.
Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals
Neverette NC, Dumond JB, McMahon DK, Devanathan AS. Clin Pharmacol Ther. 2025;117:353–367. Published online 2024 Sep 25. doi: 10.1002/cpt.3447. Correction in: Clin Pharmacol Ther. 2025;117:1470. PMCID: PMC11739746.
Human memory CD4+ T-cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses
Stetsenko V, Gail DP, Reba S, Suzart VG, Sandhu AK, Sette A, Dezfulian MH, Lindestam Arlehamn CS, Carpenter SM. Version 1. bioRxiv. Preprint. 2025:doi: 10.1101/2025.02.23.639515. PMCID: PMC11888249.
Protocol for the intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4+ T cell model.
Mbonye U, Agaponova A, Yang M, and Karn J. STAR Protoc. 2024;5:103398. doi: 10.1016/j.xpro.2024.103398. Epub 2024 Oct 18. PMID: 39425934. PMCID: PMC11513541.
Deciphering the role of endothelial granulocyte macrophage-CSF in chronic inflammation associated with HIV.
Panigrahi S, Mayne E, Louw S, Funderburg NT, Chakraborty A, Jacobson JM, Carpenter SM, Lederman MM, Freeman ML, Sieg SF. iScience. 2024;27:110909. doi: 10.1016/j.isci.2024.110909. PMID: 39391731. PMCID: PMC11465086.
The Current Pipeline of Antiretroviral Therapy: Expanding Options and Filling Gaps.
Li Y, Choudhary M, Mellors JW. Infect Dis Clin North Am. 2024;38:395-408. doi: 10.1016/j.idc.2024.04.001. Epub 2024 Jun 13. PMID: 38876905.
Simultaneous quantification of five antiretrovirals in human tissues using ultra-high performance liquid chromatography-tandem mass spectrometry methods for therapeutic drug monitoring at the sites of action.
West 3rd RE, Oberly PJ, Saylor AJ, Riddler SA, Nolin TD, Devanathan AS. J Chromatogr B Analyt Technol Biomed Life Sci. 2024;1241:124164. doi: 10.1016/j.jchromb.2024.124164. Epub 2024 May 25. PMID: 38823149. PMCID: PMC11215648.
Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation.
Kizito F, Nguyen K, Mbonye U, Shukla M, Luttge B, Checkley MA, Agaponova A, Leskov K, Karn J. Proc Natl Acad Sci U S A. 2024;121:e2202003121. doi: 10.1073/pnas.2202003121. Epub 2024 Apr 26. PMID: 38669184. PMCID: PMC11067448.
Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses.
Meyerowitz EA, Li Y. Clin Infect Dis. 2024;78:908-917. doi: 10.1093/cid/ciad685. PMID: 37949817; PMCID: PMC11487108.
The cell biology of HIV-1 latency and rebound.
Mbonye U, Karn J. Retrovirology. 2024;21:6. doi: 10.1186/s12977-024-00639-w. PMID: 38580979. PMCID: PMC10996279.
Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods to quantify antiretroviral therapy concentrations in human plasma for therapeutic drug monitoring.
West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. J Pharm Biomed Anal. 2024;240:115932. doi: 10.1016/j.jpba.2023.115932. Epub 2023 Dec 30. PMID: 38198884. PMCID: PMC10922569.
SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency.
Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. Sci Transl Med. 2024;16:eadk1599. doi: 10.1126/scitranslmed.adk1599. Epub 2024 Jan 24. PubMed PMID: 38266109.
SARS-CoV-2 Viral Clearance and Evolution Varies by Extent of Immunodeficiency
Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynold Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. Version 2. medRxiv. Preprint. 2023;doi: 10.1101/2023.07.31.23293441. Published in: Sci Transl Med. 2024 Jan 24; 16(731): eadk1599. PMCID: PMC10418302.
Viral and host mediators of non-suppressible HIV-1 viremia.
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Nat Med. 2023;29:3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. PubMed PMID: 37957382. PMCID: PMC10719098.
Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: application to therapeutic monitoring.
West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. J Chromatogr B Analyt Technol Biomed Life Sci. 2023;1230:123905. doi: 10.1016/j.jchromb.2023.123905. Epub 2023 Oct 15. PMID: 37866010. PMCID: PMC10842204.
Mycobacterium tuberculosis impairs human memory CD4+ T cell recognition of M2 but not M1-like macrophages
Gail DP, Suzart VG, Du W, Sandhu AK, Jarvela J, Nantongo M, Mwebaza I, Panigrahi S, Freeman ML, Canaday DH, Boom WH, Silver RF, Carpenter SM. iScience. 2023;26:107706. Published online 2023 Aug 23. doi: 10.1016/j.isci.2023.107706. PMCID: PMC10485162.
New insights into transcription elongation control of HIV latency and rebound.
Mbonye U, Kizito F, Karn J. New insights into transcription elongation control of HIV latency and rebound. Trends Immunol. 2023;44:60-71. doi: 10.1016/j.it.2022.11.003. Epub 2022 Dec 8. PMID: 36503686.