Rustbelt CFAR Publications
Lenacapavir: Playing the Long Game in the New Era of Antiretrovirals
Neverette NC, Dumond JB, McMahon DK, Devanathan AS. Clin Pharmacol Ther. 2025 Feb; 117(2): 353–367. Published online 2024 Sep 25. doi: 10.1002/cpt.3447. Correction in: Clin Pharmacol Ther. 2025 May; 117(5): 1470. PMCID: PMC11739746.
Human memory CD4+ T-cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses
Stetsenko V, Gail DP, Reba S, Suzart VG, Sandhu AK, Sette A, Dezfulian MH, Lindestam Arlehamn CS, Carpenter SM. Version 1. bioRxiv. Preprint. 2025 Feb 27. doi: 10.1101/2025.02.23.639515. PMCID: PMC11888249.
Protocol for the intracellular immunofluorescence measurements of latent HIV reactivation in a primary CD4+ T cell model.
Mbonye U, Agaponova A, Yang M, and Karn J. STAR Protoc. 2024 Dec 20;5(4):103398. doi: 10.1016/j.xpro.2024.103398. Epub 2024 Oct 18. PMID: 39425934 PMCID: PMC11513541.
Deciphering the role of endothelial granulocyte macrophage-CSF in chronic inflammation associated with HIV.
Panigrahi S, Mayne E, Louw S, Funderburg NT, Chakraborty A, Jacobson JM, Carpenter SM, Lederman MM, Freeman ML, Sieg SF. iScience. 2024 Sep 11;27(10):110909. doi: 10.1016/j.isci.2024.110909. PMID: 39391731; PMCID: PMC11465086.
The Current Pipeline of Antiretroviral Therapy: Expanding Options and Filling Gaps.
Li Y, Choudhary M, Mellors JW. Infect Dis Clin North Am. 2024 Sep;38(3):395-408. doi: 10.1016/j.idc.2024.04.001. Epub 2024 Jun 13. PMID: 38876905.
Simultaneous quantification of five antiretrovirals in human tissues using ultra-high performance liquid chromatography-tandem mass spectrometry methods for therapeutic drug monitoring at the sites of action.
West 3rd RE, Oberly PJ, Saylor AJ, Riddler SA, Nolin TD, Devanathan AS. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Jul 1:1241:124164. doi: 10.1016/j.jchromb.2024.124164. Epub 2024 May 25. PMID: 38823149 PMCID: PMC11215648.
Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation.
Kizito F, Nguyen K, Mbonye U, Shukla M, Luttge B, Checkley MA, Agaponova A, Leskov K, Karn J. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2202003121. doi: 10.1073/pnas.2202003121. Epub 2024 Apr 26. PMID: 38669184 PMCID: PMC11067448.
Review: The Landscape of Antiviral Therapy for COVID-19 in the Era of Widespread Population Immunity and Omicron-Lineage Viruses.
Meyerowitz EA, Li Y. Clin Infect Dis. 2024 Apr 10;78(4):908-917. doi: 10.1093/cid/ciad685. PMID: 37949817; PMCID: PMC11487108.
The cell biology of HIV-1 latency and rebound.
Mbonye U, Karn J. Retrovirology. 2024 Apr 5;21(1):6. doi: 10.1186/s12977-024-00639-w. PMID: 38580979 PMCID: PMC10996279.
Development and validation of ultra-high performance liquid chromatography-tandem mass spectrometry methods to quantify antiretroviral therapy concentrations in human plasma for therapeutic drug monitoring.
West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. J Pharm Biomed Anal. 2024 Mar 15:240:115932. doi: 10.1016/j.jpba.2023.115932. Epub 2023 Dec 30. PMID: 38198884 PMCID: PMC10922569.
SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency.
Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. Sci Transl Med. 2024 Jan 24;16(731):eadk1599. doi: 10.1126/scitranslmed.adk1599. Epub 2024 Jan 24. PubMed PMID: 38266109.
SARS-CoV-2 Viral Clearance and Evolution Varies by Extent of Immunodeficiency
Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynold Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. Version 2. medRxiv. Preprint. 2023 Aug 7. doi: 10.1101/2023.07.31.23293441. Published in: Sci Transl Med. 2024 Jan 24; 16(731): eadk1599. PMCID: PMC10418302.
Viral and host mediators of non-suppressible HIV-1 viremia.
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, Giguel F, Lian X, Deo R, Gillespie E, Chishti R, Abrha S, Adams T, Siagian A, Dorazio D, Anderson PL, Deeks SG, Lederman MM, Yawetz S, Kuritzkes DR, Lichterfeld MD, Sieg S, Tsibris A, Carrington M, Brumme ZL, Castillo-Mancilla JR, Engelman AN, Gaiha GD, Li JZ. Nat Med. 2023 Dec;29(12):3212-3223. doi: 10.1038/s41591-023-02611-1. Epub 2023 Nov 13. PubMed PMID: 37957382; PubMed Central PMCID: PMC10719098.
Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry method for quantifying lenacapavir plasma concentrations: application to therapeutic monitoring.
West 3rd RE, Oberly PJ, Riddler SA, Nolin TD, Devanathan AS. J Chromatogr B Analyt Technol Biomed Life Sci. 2023 Nov 15:1230:123905. doi: 10.1016/j.jchromb.2023.123905. Epub 2023 Oct 15. PMID: 37866010 PMCID: PMC10842204.
Mycobacterium tuberculosis impairs human memory CD4+ T cell recognition of M2 but not M1-like macrophages
Gail DP, Suzart VG, Du W, Sandhu AK, Jarvela J, Nantongo M, Mwebaza I, Panigrahi S, Freeman ML, Canaday DH, Boom WH, Silver RF, Carpenter SM. iScience. 2023 Sep 15; 26(9): 107706. Published online 2023 Aug 23. doi: 10.1016/j.isci.2023.107706. PMCID: PMC10485162.
New insights into transcription elongation control of HIV latency and rebound.
Mbonye U, Kizito F, Karn J. New insights into transcription elongation control of HIV latency and rebound. Trends Immunol. 2023 Jan;44(1):60-71. doi: 10.1016/j.it.2022.11.003. Epub 2022 Dec 8. PMID: 36503686.