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Dr. Nicolas Paul Sluis-Cremer, PhD

Professor of Medicine; Associate Chief of Research, Division of Infectious Diseases

Rustbelt CFAR Role: Co-Director, Rustbelt CFAR; Director, Core B
Dr. Sluis-Cremer's laboratory uses a multi-disciplinary approach that includes biophysics, biochemistry, virology, and analysis of clinical samples to gain insight into the mechanisms of action of antiretroviral drugs; antiviral and antimicrobial drug resistance; and understanding how HIV-1 persists in infected individuals despite potent antiretroviral therapy. His lab uses state-of-the-art biophysical methods, including transient kinetic and single-molecule approaches, to define how small molecules affect retroviral enzyme function, the intramolecular protein conformational dynamics, and the intermolecular enzyme-substrate interactions. Dr. Sluis-Cremer's HIV-1 resistance research focuses on identifying drug resistance mutations that are selected in infected-individuals failing therapy, defining the mechanisms by which these mutations decrease drug susceptibility, and predicting how acquired or transmitted drug resistance mutations impact treatment options. In regard to HIV-1 persistence, the lab focuses on characterizing the latent pool of HIV-1 infection that resides in resting CD4+ T cells, in particular the naive and central memory subsets, using novel primary cell models of HIV-1 latency and by studying purified subsets of the resting CD4+ T cell population from HIV-infected individuals on suppressive antiretroviral therapy.

Contact

Phone: +1 412-648-8457
University of Pittsburgh School of Medicine
Department of Medicine, Division of Infectious Diseases
S817 Scaife Hall, 3550 Terrace Street
Pittsburgh, Pennsylvania 15261
United States

Email Groups

List of email groups belonging to this person
Email Group Address Description
cfarpittcalls@rustbeltcfar.org Rustbelt CFAR Pitt Internal Calls
cfarpittmembers@rustbeltcfar.org Rustbelt CFAR Pitt Members
cfarehe@rustbeltcfar.org Rustbelt CFAR Ending the HIV Epidemic SWG
cfarsg@rustbeltcfar.org Rustbelt CFAR HIV Across the Lifespan SWG