Reversing HIV-1 latency across clades by targeting RasGRP1-dependent biogenesis of P-TEFb, presented by Uri Mbonye
The Sex and Gender Scientific Working Group of the Rustbelt Center for AIDS Research is hosting a presentation by Dr. Uri Mbonye, PhD, Senior Instructor, Molecular Biology and Microbiology, Case Western Reserve University
In an ex vivo primary cell model of HIV-1 latency, we have observed that synthetic lipophilic compounds known as DAG indololactones can reactivate latent HIV specifically through a RasGRP1-mediated ERK signaling pathway that stimulates P-TEFb expression. Uri's presentation will discuss this project, which was recently funded by a Rusbelt CFAR developmental award and has endeavored to determine whether the HIV-1 latency reversal responses to DAG-indololactones are equally effective in samples from women and men living with HIV and across multiple HIV clades.
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